CITED2 and NCOR2 in anti-oestrogen resistance and progression of breast cancer.

ABSTRACT:

Background

Endocrine therapies of breast cancer are effective but ultimately fail because of the development of treatment resistance. We have previously revealed several genes leading to tamoxifen resistance in vitro by retroviral insertion mutagenesis. To understand the manner in which these genes yield tamoxifen resistance, their effects on global gene expression were studied and those genes resulting in a distinct gene expression profile were further investigated for their clinical relevance.

Methods

Gene expression profiles of 69 human breast cancer cell lines that were made tamoxifen resistant through retroviral insertion mutagenesis were obtained using oligonucleotide arrays and analysed with bioinformatic tools. mRNA levels of NCOR2 and CITED2 in oestrogen receptor-po

SUBMITTER: van Agthoven T 

PROVIDER: S-EPMC2788259 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature