Clinical utility of five genetic variants for predicting prostate cancer risk and mortality.

ABSTRACT:

Background

A recent report suggests that the combination of five single-nucleotide polymorphisms (SNPs) at 8q24, 17q12, 17q24.3 and a family history of the disease may predict risk of prostate cancer. The present study tests the performance of these factors in prediction models for prostate cancer risk and prostate cancer-specific mortality.

Methods

SNPs were genotyped in population-based samples from Caucasians in King County, Washington. Incident cases (n = 1,308), aged 35-74, were compared to age-matched controls (n = 1,266) using logistic regression to estimate odds ratios (OR) associated with genotypes and family history. Cox proportional hazards models estimated hazard ratios for prostate cancer-specific mortality according to genotypes.

Results

The combination

SUBMITTER: Salinas CA 

PROVIDER: S-EPMC2788301 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature