Protein comparison at the domain architecture level.

ABSTRACT:

Background

The general method used to determine the function of newly discovered proteins is to transfer annotations from well-characterized homologous proteins. The process of selecting homologous proteins can largely be classified into sequence-based and domain-based approaches. Domain-based methods have several advantages for identifying distant homology and homology among proteins with multiple domains, as compared to sequence-based methods. However, these methods are challenged by large families defined by 'promiscuous' (or 'mobile') domains.

Results

Here we present a measure, called Weighed Domain Architecture Comparison (WDAC), of domain architecture similarity, which can be used to identify homolog of multidomain proteins. To distinguish these promiscuous domains fro

SUBMITTER: Lee B 

PROVIDER: S-EPMC2788356 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature