Alternative paths in HIV-1 targeted human signal transduction pathways.

ABSTRACT:

Background

Human immunodeficiency virus-1 (HIV-1) has a minimal genome of only 9 genes, which encode 15 proteins. HIV-1 thus depends on the human host for virtually every aspect of its life cycle. The universal language of communication in biological systems, including between pathogen and host, is via signal transduction pathways. The fundamental units of these pathways are protein protein interactions. Understanding the functional significance of HIV-1, human interactions requires viewing them in the context of human signal transduction pathways.

Results

Integration of HIV-1, human interactions with known signal transduction pathways indicates that the majority of known human pathways have the potential to be effected through at least one interaction with an HIV-1 protein

SUBMITTER: Balakrishnan S 

PROVIDER: S-EPMC2788384 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature