Human liver rate-limiting enzymes influence metabolic flux via branch points and inhibitors.

ABSTRACT:

Background

Rate-limiting enzymes, because of their relatively low velocity, are believed to influence metabolic flux in pathways. To investigate their regulatory role in metabolic networks, we look at the global organization and interactions between rate-limiting enzymes and compounds such as branch point metabolites and enzyme inhibitors in human liver.

Results

Based on 96 rate-limiting enzymes and 132 branch point compounds from human liver, we found that rate-limiting enzymes surrounded 76.5% of branch points. In a compound conversion network from human liver, the 128 branch points involved showed a dramatically higher average degree, betweenness centrality and closeness centrality as a whole. Nearly half of the in vivo inhibitors were products of rate-limiting enzymes, a

SUBMITTER: Zhao M 

PROVIDER: S-EPMC2788385 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature