Prohibitin is a novel regulator of antioxidant response that attenuates colonic inflammation in mice.

ABSTRACT:

Background & aims

Increased free radicals and/or impaired antioxidant defenses have been shown to play a pathogenetic role in human and animal models of inflammatory bowel disease. Our previous studies showed that prohibitin (PHB) levels are decreased during colitis and that cultured intestinal epithelial cells overexpressing PHB are protected from oxidative stress. This study investigated the effect of intestinal epithelial cell-specific PHB overexpression on oxidative stress associated with experimental colitis and the potential mechanism by which PHB functions as an antioxidant using PHB transgenic mice.

Methods

Colitis was induced using 2 established mouse models (Salmonella typhimurium and dextran sodium sulfate) in PHB transgenic mice and wild-type littermates. Oxidati

SUBMITTER: Theiss AL 

PROVIDER: S-EPMC2788399 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature