The Bifidobacterium dentium Bd1 genome sequence reflects its genetic adaptation to the human oral cavity.

ABSTRACT: Bifidobacteria, one of the relatively dominant components of the human intestinal microbiota, are considered one of the key groups of beneficial intestinal bacteria (probiotic bacteria). However, in addition to health-promoting taxa, the genus Bifidobacterium also includes Bifidobacterium dentium, an opportunistic cariogenic pathogen. The genetic basis for the ability of B. dentium to survive in the oral cavity and contribute to caries development is not understood. The genome of B. dentium Bd1, a strain isolated from dental caries, was sequenced to completion to uncover a single circular 2,636,368 base pair chromosome with 2,143 predicted open reading frames. Annotation of the genome sequence revealed multiple ways in which B. dentium has adapted to the oral environment through specialize

SUBMITTER: Ventura M 

PROVIDER: S-EPMC2788695 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature