Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women.

ABSTRACT:

Background

Although several studies suggest that genetic factors are associated with human UTI susceptibility, the role of DNA variation in regulating early in vivo urine inflammatory responses has not been fully examined. We examined whether candidate gene polymorphisms were associated with altered urine inflammatory profiles in asymptomatic women with or without bacteriuria.

Methodology

We conducted a cross-sectional analysis of asymptomatic bacteriuria (ASB) in 1,261 asymptomatic women ages 18-49 years originally enrolled as participants in a population-based case-control study of recurrent UTI and pyelonephritis. We genotyped polymorphisms in CXCR1, CXCR2, TLR1, TLR2, TLR4, TLR5, and TIRAP in women with and without ASB. We collected urine samples and measured levels of u

SUBMITTER: Hawn TR 

PROVIDER: S-EPMC2788705 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature