Osteoblast maturation occurs in overlapping proximal-distal compartments during fin regeneration in zebrafish.

ABSTRACT: During fin regeneration, osteoblasts must continually differentiate for outgrowth of the bony fin rays. Bone maturity increases in a distal-proximal manner, and osteoblast maturation can be detected similarly when following gene expression. We find that early markers for osteoblast differentiation are expressed in a discrete domain at the distal end of the fin, just proximal to the adjacent germinal compartment of dividing cells. Matrix genes, required at later stages developmentally, are expressed in a population of cells proximally to the early genes. A marker for mature osteoblasts is expressed in cells further proximal. These domains of gene expression are partially overlapping, perhaps revealing additional levels of osteoblast maturity. We suggest a model for growth where new cells ar

SUBMITTER: Brown AM 

PROVIDER: S-EPMC2788789 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature