Cerebrovascular disease in childhood cancer survivors: A Children's Oncology Group Report.

ABSTRACT:

Background

Curative therapy for childhood cancer has dramatically improved over past decades. Therapeutic radiation has been instrumental in this success. Unfortunately, irradiation is associated with untoward effects, including stroke and other cerebrovascular disease (CVD). The Children's Oncology Group (COG) has developed guidelines for screening survivors at risk for persistent or late sequelae of cancer therapy.

Objectives

This review summarizes the pathophysiology and relevant manifestations of radiation-induced CVD and outlines the specific patient groups at risk for early-onset stroke. The reader will be alerted to the availability of the COG recommendations for monitoring, and, when applicable, specific screening and treatment recommendations will be highlighted.

SUBMITTER: Morris B 

PROVIDER: S-EPMC2788797 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature