Age, Alzheimer disease, and brain structure.

ABSTRACT:

Background

Lack of clear understanding remains on the overlapping atrophy patterns of aging and early Alzheimer disease (AD) pathology in gray matter (GM) of the brain in vivo.

Objective

To evaluate the independent and overlapping patterns of GM atrophy in normal aging and AD.

Methods

A total of 169 cognitively normal subjects and 33 persons with probable AD enrolled in the longitudinal Cardiovascular Health Study-Cognition Study underwent 3-dimensional volumetric MRI scans. Controls remained cognitively normal for at least 5 years after their MRI scans and the probable AD subjects were relatively early in their clinical course with an average modified Mini-Mental State Examination score of 76/100. The scans were analyzed using voxel-based morphometry adjusting for to

SUBMITTER: Raji CA 

PROVIDER: S-EPMC2788799 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature