Evaluation of optic neuropathy in multiple sclerosis using low-contrast visual evoked potentials.

ABSTRACT:

Background

Contrast acuity (identification of low-contrast letters on a white background) is frequently reduced in patients with demyelinating optic neuropathy associated with multiple sclerosis (MS), even when high-contrast (Snellen) visual acuity is normal. Since visual evoked potentials (VEPs) induced with high-contrast pattern-reversal stimuli are typically increased in latency in demyelinating optic neuropathy, we asked if VEPs induced with low-contrast stimuli would be more prolonged and thus helpful in identifying demyelinating optic neuropathy in MS.

Methods

We studied 15 patients with clinically definite MS and 15 age-matched normal controls. All subjects underwent a neuro-ophthalmologic assessment, including measurement of high-contrast visual acuity and low-contra

SUBMITTER: Thurtell MJ 

PROVIDER: S-EPMC2788801 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature