Convergent genetic linkage and associations to language, speech and reading measures in families of probands with Specific Language Impairment.

ABSTRACT:

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We analyzed genetic linkage and association of measures of language, speech and reading phenotypes to candidate regions in a single set of families ascertained for SLI. Sib-pair and family-based analyses were carried out for candidate gene loci for Reading Disability (RD) on chromosomes 1p36, 3p12-q13, 6p22, and 15q21, and the speech-language candidate region on 7q31 in a sample of 322 participants ascertained for Specific Language Impairment (SLI). Replication or suggestive replication of linkage was obtained in all of these regions, but the evidence suggests that the genetic influences may not be identical for the three domains. In particular, linkage analysis replicated the influence of genes on chromosome 6p for all three domains, but association analysis indicated t

SUBMITTER: Rice ML 

PROVIDER: S-EPMC2788915 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature