Go contributes to olfactory reception in Drosophila melanogaster.

ABSTRACT:

Background

Seven-transmembrane receptors typically mediate olfactory signal transduction by coupling to G-proteins. Although insect odorant receptors have seven transmembrane domains like G-protein coupled receptors, they have an inverted membrane topology and function as ligand-gated cation channels. Consequently, the involvement of cyclic nucleotides and G proteins in insect odor reception is controversial. Since the heterotrimeric Goalpha subunit is expressed in Drosophila olfactory receptor neurons, we reasoned that Go acts together with insect odorant receptor cation channels to mediate odor-induced physiological responses.

Results

To test whether Go dependent signaling is involved in mediating olfactory responses in Drosophila, we analyzed electroantennogram and single

SUBMITTER: Chatterjee A 

PROVIDER: S-EPMC2789035 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature