Detection of treatment-induced changes in signaling pathways in gastrointestinal stromal tumors using transcriptomic data.

ABSTRACT: Cell signaling plays a central role in the etiology of cancer. Numerous therapeutics in use or under development target signaling proteins; however, off-target effects often limit assignment of positive clinical response to the intended target. As direct measurements of signaling protein activity are not generally feasible during treatment, there is a need for more powerful methods to determine if therapeutics inhibit their targets and when off-target effects occur. We have used the Bayesian Decomposition algorithm and data on transcriptional regulation to create a novel methodology, Differential Expression for Signaling Determination (DESIDE), for inferring signaling activity from microarray measurements. We applied DESIDE to deduce signaling activity in gastrointestinal stromal tumor cel

SUBMITTER: Ochs MF 

PROVIDER: S-EPMC2789202 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature