Association of TGFBR2 polymorphism with risk of sudden cardiac arrest in patients with coronary artery disease.

ABSTRACT:

Background

Transforming growth factor ss (TGFss) signaling has been shown to promote myocardial fibrosis and remodeling with coronary artery disease (CAD), and previous studies show a major role for fibrosis in the initiation of malignant ventricular arrhythmias (VA) and sudden cardiac arrest (SCA). Common single nucleotide polymorphisms (SNPs) in TGFss pathway genes may be associated with SCA.

Objective

We examined the association of common SNPs among 12 candidate genes in the TGFss pathway with the risk of SCA.

Methods

SNPs (n = 617) were genotyped in a case-control study comparing 89 patients with CAD and SCA caused by VA to 520 healthy control subjects.

Results

Nineteen SNPs among 5 genes (TGFB2, TGFBR2, SMAD1, SMAD3, SMAD6) were associated with SCA after a

SUBMITTER: Tseng ZH 

PROVIDER: S-EPMC2789271 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature