Bistability of mitochondrial respiration underlies paradoxical reactive oxygen species generation induced by anoxia.

ABSTRACT: Increased production of reactive oxygen species (ROS) in mitochondria underlies major systemic diseases, and this clinical problem stimulates a great scientific interest in the mechanism of ROS generation. However, the mechanism of hypoxia-induced change in ROS production is not fully understood. To mathematically analyze this mechanism in details, taking into consideration all the possible redox states formed in the process of electron transport, even for respiratory complex III, a system of hundreds of differential equations must be constructed. Aimed to facilitate such tasks, we developed a new methodology of modeling, which resides in the automated construction of large sets of differential equations. The detailed modeling of electron transport in mitochondria allowed for the identific

SUBMITTER: Selivanov VA 

PROVIDER: S-EPMC2789320 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature