Spatial and temporal analysis of gene expression during growth and fusion of the mouse facial prominences.

ABSTRACT: Orofacial malformations resulting from genetic and/or environmental causes are frequent human birth defects yet their etiology is often unclear because of insufficient information concerning the molecular, cellular and morphogenetic processes responsible for normal facial development. We have, therefore, derived a comprehensive expression dataset for mouse orofacial development, interrogating three distinct regions - the mandibular, maxillary and frontonasal prominences. To capture the dynamic changes in the transcriptome during face formation, we sampled five time points between E10.5-E12.5, spanning the developmental period from establishment of the prominences to their fusion to form the mature facial platform. Seven independent biological replicates were used for each sample ensuring r

SUBMITTER: Feng W 

PROVIDER: S-EPMC2789411 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature