GLI1 genotypes do not predict basal cell carcinoma risk: a case control study.

ABSTRACT:

Background

Susceptibility to basal cell carcinoma results from complex interactions between ultraviolet radiation exposure and genetic factors. The GLI1 oncogene is believed to play a role in the genesis of these tumors. We determined whether GLI1 polymorphisms were risk factors for developing basal cell carcinoma, either alone or in combination with patterns of past sun exposure, and whether there were functional differences among different GLI1 haplotypes.

Results

GLI1 genotypes at c.2798 and c.3298 from 201 basal cell carcinoma patients were compared to 201 age and sex-matched controls. Neither genotype nor haplotype frequencies differed between cases and controls. However, the odds of developing basal cell carcinoma on the trunk compared to the head/neck appeared somewha

SUBMITTER: Watson A 

PROVIDER: S-EPMC2789726 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature