Influence of CYP2C9 and VKORC1 on warfarin response during initiation of therapy.

ABSTRACT:

Background

Although multiple reports have documented the influence of CYP2C9 and VKORC1 variants on warfarin dose, risk of over-anticoagulation and hemorrhage, their influence on anticoagulation maintenance and individual proportion of time spent in target INR range (PPTR) is limited. Moreover the potential benefit of genotype-guided dosing implemented after initiation of therapy in a racially diverse population has not been explored. Herein we present the influence of CYP2C9 and VKORC1 C1173T on warfarin response during the first 30 days of therapy.

Methods

Warfarin dose was empirically determined in 250 African Americans 271 European Americans. The influence of CYP2C9 and VKORC1 on rate of INR increase, anticoagulation maintenance, risk of over-anticoagulation, and change

SUBMITTER: Limdi NA 

PROVIDER: S-EPMC2789741 | biostudies-literature | 2009 Jul-Aug

REPOSITORIES: biostudies-literature