A mixture model approach in gene-gene and gene-environmental interactions for binary phenotypes.

ABSTRACT: In translational research, a genetic association study of a binary outcome has a twofold aim: test whether genetic/environmental variables or their combinations are associated with a clinical phenotype, and determine how those combinations are grouped to predict the phenotype (i.e., which combinations have a similarly distributed phenotype, and which ones have differently distributed phenotypes). The second part of this aim has high clinical appeal, because it can directly facilitate clinical decisions. Although traditional logistic regression can detect gene-gene or gene-environmental interaction effects on binary phenotypes, they cannot decisively determine how genotype combinations are grouped to predict the phenotype. Our proposed mixture model approach is valuable in this context. It

SUBMITTER: Li L 

PROVIDER: S-EPMC2790052 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature