Burst-time-dependent plasticity robustly guides ON/OFF segregation in the lateral geniculate nucleus.

ABSTRACT: Spontaneous retinal activity (known as "waves") remodels synaptic connectivity to the lateral geniculate nucleus (LGN) during development. Analysis of retinal waves recorded with multielectrode arrays in mouse suggested that a cue for the segregation of functionally distinct (ON and OFF) retinal ganglion cells (RGCs) in the LGN may be a desynchronization in their firing, where ON cells precede OFF cells by one second. Using the recorded retinal waves as input, with two different modeling approaches we explore timing-based plasticity rules for the evolution of synaptic weights to identify key features underlying ON/OFF segregation. First, we analytically derive a linear model for the evolution of ON and OFF weights, to understand how synaptic plasticity rules extract input firing properties

SUBMITTER: Gjorgjieva J 

PROVIDER: S-EPMC2790088 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature