Association of parental dementia with cognitive and brain MRI measures in middle-aged adults.

ABSTRACT:

Objectives

Studies of autosomal dominant Alzheimer disease (AD) have shown structural and cognitive changes in mutation carriers decades prior to clinical disease. Whether such changes are detectable in offspring of persons with sporadic dementia remains unknown. We related prospectively verified parental dementia to brain MRI and cognitive testing in the offspring, within a 2-generational community-based cohort.

Methods

A total of 717 Framingham offspring (mean age: 59 +/- 8 years) were studied. In multivariate analyses, we compared offspring with and without verified parental dementia (and AD) for 1) performance on tests of memory, abstract reasoning, and cognitive flexibility, and 2) volumetric brain MRI measures of total cerebral brain volume (TCBV), hippocampal volume (

SUBMITTER: Debette S 

PROVIDER: S-EPMC2790222 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature