Distinct inherited metastasis susceptibility exists for different breast cancer subtypes: a prognosis study.

ABSTRACT:

Introduction

Previous studies in mouse models and pilot epidemiology studies have demonstrated that inherited polymorphisms are associated with inherited risk of tumor progression and poor outcome in human breast cancer. To extend these studies and gain better understanding of the function of inherited polymorphism in breast cancer progression, a validation prognosis study was performed in a large independent breast cancer patient population.

Methods

The study population consisted of 1863 Dutch patients with operable primary breast cancer from Rotterdam, The Netherlands. Genomic DNA was genotyped for the missense Pro436Leu RRP1B single nucleotide polymorphism (SNP) rs9306160 and the intronic SIPA1 SNP rs2448490 by SNP-specific PCR.

Results

A significant association of

SUBMITTER: Hsieh SM 

PROVIDER: S-EPMC2790856 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature