An experimental loop design for the detection of constitutional chromosomal aberrations by array CGH.

ABSTRACT:

Background

Comparative genomic hybridization microarrays for the detection of constitutional chromosomal aberrations is the application of microarray technology coming fastest into routine clinical application. Through genotype-phenotype association, it is also an important technique towards the discovery of disease causing genes and genomewide functional annotation in human. When using a two-channel microarray of genomic DNA probes for array CGH, the basic setup consists in hybridizing a patient against a normal reference sample. Two major disadvantages of this setup are (1) the use of half of the resources to measure a (little informative) reference sample and (2) the possibility that deviating signals are caused by benign copy number variation in the "normal" reference instead o

SUBMITTER: Allemeersch J 

PROVIDER: S-EPMC2791104 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature