A stereoselective synthesis of the bromopyrrole natural product (-)-agelastatin A.

ABSTRACT: Weaving an intricate web: A stereoselective synthesis of (-)-agelastatin A has been developed, which requires 11 steps from commercially available starting material. The application of a Rh-catalyzed intramolecular olefin aziridination reaction and the subsequent manipulation of the resulting tricyclic intermediate (see scheme) punctuate this study.

SUBMITTER: Wehn PM 

PROVIDER: S-EPMC2791535 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature