Phylogenomic analyses reveal convergent patterns of adaptive evolution in elephant and human ancestries.

ABSTRACT: Specific sets of brain-expressed genes, such as aerobic energy metabolism genes, evolved adaptively in the ancestry of humans and may have evolved adaptively in the ancestry of other large-brained mammals. The recent addition of genomes from two afrotherians (elephant and tenrec) to the expanding set of publically available sequenced mammalian genomes provided an opportunity to test this hypothesis. Elephants resemble humans by having large brains and long life spans; tenrecs, in contrast, have small brains and short life spans. Thus, we investigated whether the phylogenomic patterns of adaptive evolution are more similar between elephant and human than between either elephant and tenrec lineages or human and mouse lineages, and whether aerobic energy metabolism genes are especially well r

SUBMITTER: Goodman M 

PROVIDER: S-EPMC2791620 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature