Expression profiling after retinal detachment and reattachment: a possible role for aquaporin-0.

ABSTRACT:

Purpose

Retinal detachment (RD) is associated with acute visual loss caused by anatomic displacement of the photoreceptors and with chronic visual loss/disturbance caused by retinal remodeling and photoreceptor cell death, which may occur even after successful reattachment. The P2Y(2) receptor agonist INS37217 improves the rate of retinal reattachment in animal models of induced RD, and has been shown to also significantly enhance the rate of ERG recovery in a mouse model of RD. The identification of genes modulated by INS37217 may allow further drug discovery for treating RD and edema.

Methods

To identify genes involved in RD and subsequent reattachment, a retinal microarray screen was performed using a mouse model of RD in the presence or absence of INS37217.

Results

SUBMITTER: Farjo R 

PROVIDER: S-EPMC2792233 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature