C-type lectins from the nematode parasites Heligmosomoides polygyrus and Nippostrongylus brasiliensis.

ABSTRACT: The C-type lectin superfamily is highly represented in all metazoan phyla so far studied. Many members of this superfamily are important in innate immune defences against infection, while others serve key developmental and structural roles. Within the superfamily, many proteins contain multiple canonical carbohydrate-recognition domains (CRDs), together with additional non-lectin domains. In this report, we have studied two gastrointestinal nematode parasites which are widely used in experimental rodent systems, Heligmosomoides polygyrus and Nippostrongylus brasiliensis. From cDNA libraries, we have isolated 3 new C-type lectins from these species; all are single-CRD proteins with short additional N-terminal domains. The predicted Hp-CTL-1 protein contains 156 aa, Nb-CTL-1 191 aa and Nb-CT

SUBMITTER: Harcus Y 

PROVIDER: S-EPMC2792708 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature