Transferability and fine-mapping of genome-wide associated loci for adult height across human populations.

ABSTRACT: Human height is the prototypical polygenic quantitative trait. Recently, several genetic variants influencing adult height were identified, primarily in individuals of East Asian (Chinese Han or Korean) or European ancestry. Here, we examined 152 genetic variants representing 107 independent loci previously associated with adult height for transferability in a well-powered sample of 1,016 unrelated African Americans. When we tested just the reported variants originally identified as associated with adult height in individuals of East Asian or European ancestry, only 8.3% of these loci transferred (p-values < or =0.05 under an additive genetic model with directionally consistent effects) to our African American sample. However, when we comprehensively evaluated all HapMap variants in linkag

SUBMITTER: Shriner D 

PROVIDER: S-EPMC2792725 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature