Immune response in human cerebral cavernous malformations.

ABSTRACT:

Background and purpose

Preliminary observations suggesting the presence of B and plasma cells and oligoclonality of immunoglobulin (Ig) G in cerebral cavernous malformations (CCM) have motivated a systematic study correlating the infiltration of the immune cells with clinical activity and antigen-triggered immune response in surgically excised lesions.

Methods

Infiltration of plasma, B, T, and human leukocyte antigen-DR-expressing cells and macrophages within 23 excised CCM was related to clinical activity. Relative amounts of Ig isotypes were determined. IgG clonality of mRNA from CCM was assessed by spectratyping, cloning, and sequencing.

Results

Infiltration of the immune cells ranged widely within CCM lesions, and cells were generally coexpressed with each other.

SUBMITTER: Shi C 

PROVIDER: S-EPMC2792996 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature