The soy isoflavones for reducing bone loss (SIRBL) study: a 3-y randomized controlled trial in postmenopausal women.

ABSTRACT:

Background

Our previous study indicated that soy protein with isoflavones lessened lumbar spine bone loss in midlife women.

Objective

We examined the efficacy of isoflavones (extracted from soy protein) on bone mineral density (BMD) in nonosteoporotic postmenopausal women. We hypothesized that isoflavone tablets would spare BMD, with biological (age, body weight, serum 25-hydroxyvitamin D) and lifestyle (physical activity, dietary intake) factors modulating BMD loss.

Design

Our double-blind, randomized controlled trial (36 mo) included healthy postmenopausal women (aged 45.8-65.0 y) with intent-to-treat (n = 224) and compliant (n = 208) analyses. Treatment groups consisted of a placebo control group and 2 soy isoflavone groups (80 compared with 120 mg/d); women receiv

SUBMITTER: Alekel DL 

PROVIDER: S-EPMC2793109 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature