Cerebral hypoperfusion increases estrogen receptor abundance in the ovine fetal brain and pituitary.

ABSTRACT:

Background/aims

Estrogen is an important component of fetal neuroendocrine function in late-gestation fetal sheep; however, little is known about the regulation of estrogen receptor abundance in the brain and pituitary of fetuses. The present study was performed to test the hypotheses that estrogen receptor abundance in the fetal brain and pituitary are influenced by circulating estradiol concentrations and that they are acutely regulated after cerebral hypoperfusion.

Methods

We studied 16 time-dated fetal sheep (124-128 days gestation) that were chronically catheterized and instrumented at least 5 days before study. Four groups (n = 4 each) were studied in which fetuses received estradiol (0.25 mg/day, producing physiological increases in fetal plasma estradiol concentratio

SUBMITTER: Wood CE 

PROVIDER: S-EPMC2793328 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature