Comprehensive classification of nucleotidyltransferase fold proteins: identification of novel families and their representatives in human.

ABSTRACT: This article presents a comprehensive review of large and highly diverse superfamily of nucleotidyltransferase fold proteins by providing a global picture about their evolutionary history, sequence-structure diversity and fulfilled functional roles. Using top-of-the-line homology detection method combined with transitive searches and fold recognition, we revised the realm of these superfamily in numerous databases of catalogued protein families and structures, and identified 10 new families of nucleotidyltransferase fold. These families include hundreds of previously uncharacterized and various poorly annotated proteins such as Fukutin/LICD, NFAT, FAM46, Mab-21 and NRAP. Some of these proteins seem to play novel important roles, not observed before for this superfamily, such as regulation

SUBMITTER: Kuchta K 

PROVIDER: S-EPMC2794190 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature