Regulatory diversity of TUP1 in Cryptococcus neoformans.

ABSTRACT: Cryptococcus neoformans serotype A strains, the major cause of cryptococcosis, are distributed worldwide, while serotype D strains are more concentrated in Central Europe. We have previously shown that deletion of the global regulator TUP1 in serotype D isolates results in a novel peptide-mediated, density-dependent growth phenotype that mimics quorum sensing and is not known to exist in other fungi. Unlike for tup1Delta strains of serotype D, the density-dependent growth phenotype was found to be absent in tup1Delta strains of serotype A which had been derived from several different genetic clusters. The serotype A H99 tup1Delta strain showed less retardation in the growth rate than tup1Delta strains of serotype D, but the mating efficiency was found to be similar in both serotypes. Delet

SUBMITTER: Lee H 

PROVIDER: S-EPMC2794222 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature