Unique sequence features of the Human adenovirus 31 complete genomic sequence are conserved in clinical isolates.

ABSTRACT:

Background

Human adenoviruses (HAdV) are causing a broad spectrum of diseases. One of the most severe forms of adenovirus infection is a disseminated disease resulting in significant morbidity and mortality. Several reports in recent years have identified HAdV-31 from species A (HAdV-A31) as a cause of disseminated disease in children following haematopoetic stem cell transplantation (hSCT) and liver transplantation. We sequenced and analyzed the complete genome of the HAdV-A31 prototype strain to uncover unique sequence motifs associated with its high virulence. Moreover, we sequenced coding regions known to be essential for tropism and virulence (early transcription units E1A, E3, E4, the fiber knob and the penton base) of HAdV-A31 clinical isolates from patients with disseminate

SUBMITTER: Hofmayer S 

PROVIDER: S-EPMC2794291 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature