A gene expression signature of invasive potential in metastatic melanoma cells.

ABSTRACT:

Background

We are investigating the molecular basis of melanoma by defining genomic characteristics that correlate with tumour phenotype in a novel panel of metastatic melanoma cell lines. The aim of this study is to identify new prognostic markers and therapeutic targets that might aid clinical cancer diagnosis and management.

Principal findings

Global transcript profiling identified a signature featuring decreased expression of developmental and lineage specification genes including MITF, EDNRB, DCT, and TYR, and increased expression of genes involved in interaction with the extracellular environment, such as PLAUR, VCAN, and HIF1a. Migration assays showed that the gene signature correlated with the invasive potential of the cell lines, and external validation by using pub

SUBMITTER: Jeffs AR 

PROVIDER: S-EPMC2794539 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature