Plant SET domain-containing proteins: structure, function and regulation.

ABSTRACT: Modification of the histone proteins that form the core around which chromosomal DNA is looped has profound epigenetic effects on the accessibility of the associated DNA for transcription, replication and repair. The SET domain is now recognized as generally having methyltransferase activity targeted to specific lysine residues of histone H3 or H4. There is considerable sequence conservation within the SET domain and within its flanking regions. Previous reviews have shown that SET proteins from Arabidopsis and maize fall into five classes according to their sequence and domain architectures. These classes generally reflect specificity for a particular substrate. SET proteins from rice were found to fall into similar groupings, strengthening the merit of the approach taken. Two additional

SUBMITTER: Ng DW 

PROVIDER: S-EPMC2794661 | biostudies-literature | 2007 May-Jun

REPOSITORIES: biostudies-literature