Post-exposure prophylaxis during pandemic outbreaks.

ABSTRACT:

Background

With the rise of the second pandemic wave of the novel influenza A (H1N1) virus in the current season in the Northern Hemisphere, pandemic plans are being carefully re-evaluated, particularly for the strategic use of antiviral drugs. The recent emergence of oseltamivir-resistant in treated H1N1 patients has raised concerns about the prudent use of neuraminidase inhibitors for both treatment of ill individuals and post-exposure prophylaxis of close contacts.

Methods

We extended an established population dynamical model of pandemic influenza with treatment to include post-exposure prophylaxis of close contacts. Using parameter estimates published in the literature, we simulated the model to evaluate the combined effect of treatment and prophylaxis in minimizing morb

SUBMITTER: Moghadas SM 

PROVIDER: S-EPMC2794871 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature