Differential protein profiling as a potential multi-marker approach for TSE diagnosis.

ABSTRACT:

Background

Transmissible spongiform encephalopathy describes a family of diseases affecting both man and animals. Current tests for the diagnosis of these diseases are based on the detection of an abnormal misfolded form of the host protein PrP which is found within the central nervous and lymphoreticular systems of affected animals. Recently, concern that this marker may not be as reliable as previously thought, coupled with an urgentneed for a pre-clinical live animal test, has led to the search for alternative assays for the detection of TSE disease.

Methods

This "proof of concept" study, examines the use of differential protein expression profiling using surface enhanced laser desorption and ionisationtime of flight mass spectrometry (SELDI-TOF) for the diagnosis of TSE

SUBMITTER: Barr JB 

PROVIDER: S-EPMC2794872 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature