A genomewide association study of citalopram response in major depressive disorder.

ABSTRACT:

Background

Antidepressant response is likely influenced by genetic constitution, but the actual genes involved have yet to be determined. We have carried out a genomewide association study to determine whether common DNA variation influences antidepressant response.

Methods

Our sample is derived from Level 1 participants in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, all treated with citalopram. Association for the response phenotype included 883 responders and 608 nonresponders. For the remission phenotype, 743 subjects that achieved remission were compared with 608 nonresponders. We used a subset of single nucleotide polymorphisms (SNPs; n = 430,198) from the Affymetrix 500K and 5.0 Human SNP Arrays, and association analysis was carried out a

SUBMITTER: Garriock HA 

PROVIDER: S-EPMC2794921 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature