Autoantibody profiling to identify biomarkers of key pathogenic pathways in mucinous ovarian cancer.

ABSTRACT: Mucinous epithelial ovarian cancers are clinically and morphologically distinct from the other histopathologic subtypes of ovarian cancer. Unlike other ovarian subtypes, epidemiologic studies have indicated that tobacco exposure is a significant risk factor for developing mucinous ovarian cancer. Detection of autoantibody reactivity is useful in biomarker discovery and for explaining the role of important pathophysiologic pathways in disease. In order to study if there are specific antibody biomarkers in the plasma samples of mucinous ovarian cancer patients, we have initiated a screen by employing a 'reverse capture antibody microarray' platform that uses native host antigens derived from mucinous ovarian tissues as 'baits' for the capture of differentially labelled patient and control au

SUBMITTER: Tang L 

PROVIDER: S-EPMC2794928 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature