Gene networks and microRNAs implicated in aggressive prostate cancer.

ABSTRACT: Prostate cancer, a complex disease, can be relatively harmless or extremely aggressive. To identify candidate genes involved in causal pathways of aggressive prostate cancer, we implemented a systems biology approach by combining differential expression analysis and coexpression network analysis to evaluate transcriptional profiles using lymphoblastoid cell lines from 62 prostate cancer patients with aggressive phenotype (Gleason grade >or= 8) and 63 prostate cancer patients with nonaggressive phenotype (Gleason grade

SUBMITTER: Wang L 

PROVIDER: S-EPMC2795036 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature