Modulation of chromatin modification facilitates extinction of cocaine-induced conditioned place preference.

ABSTRACT:

Background

Recent evidence suggests that epigenetic mechanisms have an important role in the development of addictive behavior. However, little is known about the role of epigenetic mechanisms in the extinction of drug-induced behavioral changes. In this study, we examined the ability of histone deacetylase (HDAC) inhibitors to facilitate extinction and attenuate reinstatement of cocaine-induced conditioned place preference (CPP).

Methods

C57BL/6 mice were subject to cocaine-induced CPP using 20 mg/kg dose. To facilitate extinction, mice were administered an HDAC inhibitor following nonreinforced exposure to the conditioned context. To measure persistence, mice were subject to a reinstatement test using 10 mg/kg dose of cocaine.

Results

We demonstrate that HDAC inhibi

SUBMITTER: Malvaez M 

PROVIDER: S-EPMC2795056 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature