Pharmacogenetic characterization of indacaterol, a novel beta 2-adrenoceptor agonist.

ABSTRACT:

Background and purpose

Indacaterol is a novel beta(2)-adrenoceptor agonist in development for the treatment of chronic obstructive pulmonary disease. The aim of this study was to investigate the comparative pharmacology of indacaterol in recombinant cells expressing the common polymorphic variants of the human beta(2)-adrenoceptor and in human primary airway smooth muscle (ASM) cells.

Experimental approach

Chinese hamster ovarian-K1 cell lines expressing high and low levels of the common human beta(2)-adrenoceptor variants were generated [Gly16-Glu27-Val34-Thr164(GEVT), RQVT, GQVT] and also the rare GQVI variant. Human primary ASM cells were isolated from explants of trachealis muscle. Adenosine-3',5'-cyclic-monophosphate production was used as an outcome measure.

Key res

SUBMITTER: Sayers I 

PROVIDER: S-EPMC2795231 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature