Identification of a polyprenylphosphomannosyl synthase involved in the synthesis of mycobacterial mannosides.

ABSTRACT: We report on the identification of a glycosyltransferase (GT) from Mycobacterium tuberculosis H37Rv, Rv3779, of the membranous GT-C superfamily responsible for the direct synthesis of polyprenyl-phospho-mannopyranose and thus indirectly for lipoarabinomannan, lipomannan, and the higher-order phosphatidyl-myo-inositol mannosides.

SUBMITTER: Scherman H 

PROVIDER: S-EPMC2795309 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature