Comparison of simvastatin and metformin in treatment of polycystic ovary syndrome: prospective randomized trial.

ABSTRACT:

Context

Polycystic ovary syndrome (PCOS) is characterized by ovarian dysfunction and hyperandrogenism; it is also associated with increased cardiovascular risks such as adverse lipid profile and endothelial dysfunction. Metformin and, more recently, statins have been shown to improve endocrine and metabolic aspects of PCOS.

Objective

The aim of the study was to compare effects of simvastatin and metformin on PCOS.

Design

In a prospective trial, women with PCOS (n = 136) were randomized to simvastatin (S), metformin (M), or simvastatin plus metformin (SM) groups. Evaluations were performed at baseline and after 3 months.

Setting

The study was conducted at an academic medical center.

Primary outcome

The change of serum total testosterone was measured.

R

SUBMITTER: Banaszewska B 

PROVIDER: S-EPMC2795658 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature