Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse.

ABSTRACT:

Background

Caloric restriction (CR) counters deleterious effects of aging and, for most mouse genotypes, increases mean and maximum lifespan. Previous analyses of microarray data have identified gene expression responses to CR that are shared among multiple mouse tissues, including the activation of anti-oxidant, tumor suppressor and anti-inflammatory pathways. These analyses have provided useful research directions, but have been restricted to a limited number of tissues, and have focused on individual genes, rather than whole-genome transcriptional networks. Furthermore, CR is thought to oppose age-associated gene expression patterns, but detailed statistical investigations of this hypothesis have not been carried out.

Results

Systemic effects of CR and aging were identifi

SUBMITTER: Swindell WR 

PROVIDER: S-EPMC2795771 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature