A conceptual mathematical model of the dynamic self-organisation of distinct cellular organelles.

ABSTRACT: Formation, degradation and renewal of cellular organelles is a dynamic process based on permanent budding, fusion and inter-organelle traffic of vesicles. These processes include many regulatory proteins such as SNAREs, Rabs and coats. Given this complex machinery, a controversially debated issue is the definition of a minimal set of generic mechanisms necessary to enable the self-organization of organelles differing in number, size and chemical composition. We present a conceptual mathematical model of dynamic organelle formation based on interacting vesicles which carry different types of fusogenic proteins (FP) playing the role of characteristic marker proteins. Our simulations (ODEs) show that a de novo formation of non-identical organelles, each accumulating a different type of FP, re

SUBMITTER: Binder B 

PROVIDER: S-EPMC2795802 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature