Association of KCNB1 to rheumatoid arthritis via interaction with HLA-DRB1.

ABSTRACT: With the rapid development of large-scale high-throughput genotyping technology, genome-wide association studies have become a popular approach to mapping genes underlying common human disorders. Some genes are discovered, but many more have not been. Because these genes were not initially identified, it is reasonable to assume that their main effect is weak. We propose a method to accommodate such a situation. It is applied to the Genetic Analysis Workshop 16 Problem 1 case-control data in which shared-epitope alleles of HLA-DRB1 show very strong association with rheumatoid arthritis. Because some previous functional studies have reported association of gene KCNB1 to rheumatoid arthritis, we evaluate whether the gene KCNB1 contributes to the genetics of rheumatoid arthritis in this data s

SUBMITTER: Xiao X 

PROVIDER: S-EPMC2795908 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature